Basic Molecular Information

Basic Information

DICL ID
DICL_CP_0347362
PubChem CID
Molecular Formula
C14H10F3N5OS
Molecular Weight
353.329 g/mol
Synonyms/Alias
[CHEMBL484353]
InChI Key
BXPZVHTYWQHTRG-UHFFFAOYSA-N
InChI
InChI=1S/C14H10F3N5OS/c1-8-12(24-21-19-8)13(23)18-9-2-4-10(5-3-9)22-7-6-11(20-22)14(15,16)17/h2-7H,1...
IUPAC Name
4-methyl-N-[4-[3-(trifluoromethyl)pyrazol-1-yl]phenyl]thiadiazole-5-carboxamide
CAS Number
223499-30-7

Structure Information

Chemical Structure Visualization

SMILES Notation
2D Molecular Drawing
Carbon (C)
Hydrogen (H)
Oxygen (O)
Nitrogen (N)
Sulfur (S)
SDF

24 26 0 0 0 0 0 0 0 0999 V2000
-5.3561 -2.3930 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-6.0643 -1.0707 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-5.4107 0...

Experimental Data

Activity Data

Target Ion Channel
Calcium release-activated calcium channel (CRAC)
Uniprot Accession Number
Function
Inhibitor
Species
Rattus norvegicus (Rat)
IC50
IC50: 400 nM
EC50
N/A (Not available)
Ki
N/A (Not available)
Kd
N/A (Not available)
Inhibition
N/A (Not available)

Experimental Conditions

pH
Not mention
Holding Potential
Not specified
Temperature
~22 °C
Test Method
Efflux Assay ([86] Rubidium Ion)
Test Species
Not specified

Binding Information

Binding Site
Not specified
Binding Site Residue
Not specified

Disease Information

Related Disease
Not specified

References

URL
N/A (Not available)
PMID
Patent
N/A (Not available)

Computed Properties

Heavy Atom Count
24
Rotatable Bonds
3
logP
3.3033
Complexity
81.1652
TPSA (Ų)
72.7
H-Bond Donors
1
H-Bond Acceptors
6
Ring Count
3
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